Aging results partly from development of patterns of gene expression that determine specific complexes of proteins and lipids that become progressively less adequate for maintenance of brain. Aging also results from progressive uncontrolled oxidation, causing DNA damage, mitochondrial decay, chronic inflammation, and excessive cell death in brain. Data from cell, mouse, rat, and monkey models, indicate that caloric restriction (CR) inhibits development of age-related proteins and lipids, and inhibits oxidative damage by affecting expression of multiple genes that are tightly conserved across mammals, including PPARs, SREBPs, NF_kB, 17_BHSD, HO-1, GCS_h, TNF_ax, and VDAC-1 and results in inhibition of cognitive decline, inhibition of multiple diseases and increased lifespan. Several nutrients, including docosahexanoic acid, resveratrol, n-acetyl cysteine, R+ lipoic acid, and acetyl-L carnitine mimic some CR effects on gene expression. These findings offer unique support to the more macroscopic and more controversial data from medical, biochemical, nutrition, and aging research that the same nutrients can inhibit a wide spectrum of disorders, including declines of cognition, learning, memory, motor function, balance and reaction speed, and offer firm support for their use to combat brain aging.

Discover the ways in which the human brain degenerates into Alzheimer's disease and Parkinson's disease.

Examine the evidence that certain structures in our ancient mid-brain are subject to damage, from age 25 on - and what you can do to protect them.

Find out how pollution, pesticides and man-made chemicals silently destroy your brain - and acquire effective ways to prevent it.

Understand the new brain science of neuroplasticity, and how it can help your brain.

Learn the ways of the Brain Program, which can maintain, and even improve, your brain function.

Use the nutritional and lifestyle strategies of the Brain Program to increase your intelligence, enhance your memory, and enrich your learning ability, and keep them that way life-long.

Comments About 'Save Your Brain'

"I consider this to be the most important of all Dr. Colgan's writings. Get the book, and don't just sit on it; the seat of learning tends to be much higher."
Dr. Andrew Strigner, Consulting Physician, Harley St. London

"This book is a must for those who wish to improve their intelligence, memory and physical function in every aspect of their life."
Paul Meyer, Success Motivation Inc, New York times best selling author

"Dr. Colgan once again presents the latest research in a way that is easy to understand and entertaining to read. He is without a doubt one of the world's leading writers in the fields of nutrition and health."
Philip Mills, President of the Mills Group, US Entrepreneur of the Year, 2005

"Dr. Colgan's books contain detailed strategies integrating the most advanced mainstream therapies with cutting edge nutrients and holistic approaches from throughout the world."
Sam Graci, M.Ed, best selling author

"Being in the golf industry for 30 years, I notice the mental decline of my aging members. After following Dr. Colgan's brain program for years, I find myself to be the exception. The results of his strategies are very similar to improving your golf game. Start early, continue practicing, and enjoy."
Kevin Paluch, Auhtor of Par for Life, Geneva National Golf Club